12/3/15 Show feat. Gloria Tavera (Case Western) on Malaria, Immunology, and the Fight for Equal Access to Medicines

Malaria is a colossal global problem. In Africa, a child a minute perishes due to the parasite. It’s easy not to be aware of this in the US, where malaria hasn’t been a problem for many years – but 3.4 billion people (half the world’s population) lives in areas at risk of the disease.

In this episode of These Vibes Are Too Cosmic I speak with Gloria Tavera, MD/PhD student at Case Western Reserve University in Cleveland, Ohio. We discuss the general mechanics of our immune systems and malaria’s effect on it. We get in to why malaria is so difficult to treat and why so many children die from the parasite. Gloria explains the new malaria vaccine – both why it’s exciting and how it is far from a full solution (or even a full malaria vaccine), but rather an important step along the road to eradication.

In the last portion of the show we discuss another deeply important topic, and a great passion of Gloria’s: equal access to medicines worldwide. Gloria is president of the board of directors for UAEM (Universities Allied for Essential Medicines), an organization that uses a muti-tiered approach to leveling the access to affordable medications across the world, and particularly in developing countries. Gloria uses the example of insulin. In Sub-Saharan Africa people commonly die of diabetes due to the fact that insulin is rare and, when available, unaffordable. The system is stacked against them.

So, listen up, learn about our world, and get fired up!

Some extra info on malaria immunity (from Gloria Tavera):

The figures above (found here) show how an antibody, along with a set of molecules called complement, can bind a malaria parasite and keep it from invading a human red blood cell, which keeps it from surviving and reproducing.

The second figure above on that page shows how the set of molecules, called complement, bind to antibodies and make the antibodies even more effective at killing the malaria parasite and keeping it from entering human red blood cells.

Related to that video, is a petition to the World Health Organization (WHO) that we have created. We are calling on World Health Organization member states to fund a pool of money (prize funding) for researchers to create drugs, diagnostics and vaccines that are targeted to help solve diseases of major public health importance, that will be available royalty-free.

If you’re interested in going even deeper, read the recent LA Times piece from Economist Mariana Mazzucato, on problems and solutions regarding our current, global biomedical research and development system.

Playlist for the show: