Featured image is that of an interactive map of vaccine-preventable disease outbreaks across the globe, created by the Council on Foreign Relations. You can find it, and explore it yourself, at this link.
In this installment of These Vibes Are Too Cosmic, we spoke with Dr. Alexander Ploss,
professor in molecular biology here at Princeton. His research focuses on immune responses to human pathogens – specifically those infecting the liver, including hepatitis B and C viruses, yellow fever and dengue viruses and parasites causing malaria in humans. His group combines methods in tissue engineering, molecular virology and pathogenesis, and animal construction, to create and apply technologies to study human liver diseases caused by infectious diseases and if possible intervene in them. Specifically, he works to create “humanized mice” so we can study in lab mice diseases that typically only infect humans (and other very related species like great apes). In this interview, he discusses how his lab does this and the importance of this research.
I asked Professor Ploss to come speak with us because this topic of infectious diseases is incredibly important. Almost a quarter of the all human deaths worldwide occur due to infectious diseases. And, according to the WHO, in high-income countries like the United States, 7 in every 10 deaths are among people aged 70 years and older, and we perish primarily due to non-communicable diseases like cardiovascular diseases and cancer.
In contrast, in low-income countries nearly 4 in every 10 deaths are among children under 15 years, with only 2 in every 10 deaths are among people aged 70 years and older. In low income countries people predominantly die of infectious diseases like the ones studied by Professor Ploss.
Take a listen.